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Programmes/ Projects Supported by ATF

2010

Programmes / Projects supported by the AIDS Trust Fund in January 2010

MSS 180 R
Application: Development of genotyping test for improving the clinical antiretroviral treatment on Integrase inhibitor and CCR5 antagonist in Hong Kong
(Executive Summary submitted by the applicant)
Applicant: Department of Microbiology, The University of Hong Kong
Objectives: The objectives of this programme are:-
  1. To develop a new and cost effective genotyping resistance test to monitor drug resistance related mutations in the protease, reverse transcriptase and integrase region of pol gene and V3 region of env gene.
  2. To investigate a genotyping method to determine the HIV-1 tropism and estimate the prevalence of HIV-1 CCR5 variants among various genotypes prevalent in Hong Kong;
  3. To perform surveillance monitoring of the presence of primary resistance HIV-1 isolates to integrase inhibitor and CCR5 antagonist in our community;
  4. To evaluate the development of drug resistance related mutations through longitudinal monitoring after initation of ordinary HAART plus integrase inhibitor or CCR5 antagonist;
  5. To build up database on primary resistance mutations to integrase inhibitor and CCR5 antagonist and the HIV-1 tropism among various HIV-1 genotypes prevalent in Hong Kong. Information will provide clinical guidance for HIV treatment.
Project Duration: April 2010 to March 2013
Contact Person: Dr. YAM Wing-cheong
Department of Microbiology
University Pathology Building
Queen Mary Hospital Compound
The University of Hong Kong, Pokfulam, Hong Kong
Telephone: 2255 4821
Fax: 2255 1241